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Fabio Bergamin. ETH Zurich scientists have shown that statins, one of the most commonly Wintertuhr classes of pharmaceuticals, reduce beneficial brown adipose tissue.

But this is no reason to demonise these drugs, the researchers insist. A certain proportion Massage Altstetten riverwalk the adult population has not only white adipose or fatty tissue, but also the brown kind.

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This brown adipose tissue helps to convert sugar and fat into heat. People with brown adipose tissue are better at regulating their body temperature in the winter, and are less likely to suffer from excess weight or diabetes. White Stadt Winterthur pills international team of researchers led by Christian Wolfrum, Professor for Translational Nutritional Biology at ETH Zurich, has now discovered Pussy girl Altstetten the statin class of pharmaceuticals reduces the formation of brown adipose tissue.

Statins are prescribed as a way to reduce the risk of a heart attack since they reduce cholesterol levels in the blood. They are among the most commonly prescribed drugs worldwide.

Wolfrum and his colleagues have been researching brown adipose tissue for many years. Having conducted cell culture experiments, they found out that the biochemical pathway responsible for producing cholesterol plays a central role in this transformation. They also discovered that White Stadt Winterthur pills key molecule regulating the transformation is the metabolite geranylgeranyl pyrophosphate. Earlier studies showed that the cholesterol biochemical pathway is also central to the functioning of statins; Effretikon hot fm of their effects is to reduce the production of geranylgeranyl pyrophosphate.

This is why the researchers wanted to know whether statins also impact the formation of brown adipose tissue. And indeed they do, as the scientists have now shown in studies on mice and humans.

One thing the researchers did was study positron emission tomography scans of 8, patients at the University Hospital Zurich. This let them determine whether the person had brown adipose tissue. It was also known whether the patients were taking statins. Evaluating the scans shows that 6 percent of those not taking the medication had brown adipose tissue, but this tissue type was present in only Luka massage Schaffhausen little over 1 percent of those who were taking statins.

The researchers conducted a separate clinical study of 16 people at the University Hospitals of Basel and Zurich to demonstrate that statins reduce the activity of brown adipose tissue. Although the study demonstrated that statins have Ebony bbw Uzwil negative impact, Wolfrum warns against talking them.

However, statins also Whhite another negative effect: But Wolfrum stresses that even if such a link were established, that would be no reason to demonise statins.

Rather, it would become imperative to conduct further research into the mechanisms behind this and find out which patients are affected. It might then be possible to take a personalised medicine approach and continue to recommend statins to most people, while proposing alternative therapies for a small group of patients.

Balaz M et al.: Cell Metabolism, 20 Decemberdoi: Homepage Navigation Content Sitemap Search.

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