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We Riesbac data from the Efficacy Limiting Toxicity Elimination Symphony Study How to Riesbach with a toxic man between and to model risk of rejection and infection in the first year after kidney transplantation. External validation Wil county sex club performed in a study population from the Fixed-Dose Concentration-Controlled Trial patients between and Despite different temporal dynamics, rejections and severe infections had similar overall incidences in the first year after transplantation Recipient older age, deceased donor, higher number of HLA mismatches, and high risk for cytomegalovirus disease were associated with infection; deceased donor, higher number of HLA mismatches, and immunosuppressive therapy including cyclosporin A compared with tacrolimuswith rejection.
These factors were integrated into a two—dimensional risk stratification model, which defined four risk groups: External validation confirmed the applicability of the model to an independent cohort. We propose a two—dimensional risk stratification model Hoq to disentangle the individual risk for rejection and infection in the first year after kidney transplantation.
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However, intense immunosuppression inevitably increases susceptibility to infections and malignancies, some of which are infection triggered 2 — 4. As a result, the relevance of infection episodes and infection—associated allograft failures progressively increased in the last decades, and balancing the beneficial and deleterious effects of immunosuppressive therapy emerged as a critical aim in the modern transplantation era 5 — 8. Recipients of kidney transplants are a very heterogeneous patient population, and the risks for rejection and infection markedly vary among different patient subgroups 9]